ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1583509
This article is part of the Research TopicPromising Photosensitive Agents for Photodynamic TherapyView all 12 articles
Quercetin in Shengxian Decoction exhibits anti-ferroptosis protective role in myocardial infarction model via targeting DPP4/ HMOX1, based on network pharmacology and molecular docking
Provisionally accepted
- 1Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
- 2Department of Cardiovascular Medicine, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
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Background: Myocardial infarction (MI) is characterized by high morbidity. The study aimed to elucidate potential targets of Shengxian Decoction (SXD) against MI. Methods: Pairing of SXD active ingredients and MI targets was conducted employing The Chinese Medicine System Pharmacological Database, Gene Expression Omnibus, and STRING databases. The effects of SXD on MI was validated in vitro. Molecular docking was verified employing cellular thermal shift assay (CETSA). Results: Totally 40 active ingredients and 28 MI-related targets were obtained. Cross-analysis on 28 targets and cell-death-related genes identified 2 crucial ferroptosis-related targets, DPP4 and HMOX1. In CoCl2-induced hypoxic H9c2 cells, SXD could remarkably improved cell viability and inhibited cell death. Meanwhile, SXD treatment significantly affected the ferroptosis-related markers in hypoxic H9c2 cells. Molecular docking and CETSA results showed that quercetin had good binding activity with DPP4 and HMOX1. Conclusion: Important active ingredient quercetin in SXD could exert anti-ferroptosis protective roles on MI through targeting ferroptosis-related genes DPP4/ HMOX1, thereby contributing to the protective role of SXD on MI.
Keywords: Myocardial Infarction, Shengxian decoction, Quercetin, ferroptosis, Network Pharmacology
Received: 26 Feb 2025; Accepted: 31 Mar 2025.
Copyright: © 2025 Zhai, Fu, Yang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yabin Zhou, Department of Cardiovascular Medicine, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
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