REVIEW article
Front. Pharmacol.
Sec. Pharmacology of Ion Channels and Channelopathies
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1583487
This article is part of the Research TopicPharmacological Perspectives into Transient Receptor Potential ChannelsView all 5 articles
The role of transient receptor potential channels in chronic kidney disease-mineral and bone disorder
Provisionally accepted
- 1Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
- 2National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
- 3Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States
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Chronic kidney disease (CKD) represents a major global health challenge, frequently resulting in the development of chronic kidney disease-mineral and bone disorder (CKD-MBD). Transient receptor potential (TRP) channels, particularly the TRPV (vanilloid), TRPC (canonical), and TRPM (melastatin) subfamilies, are crucial in CKD-MBD by regulating calcium homeostasis, bone remodeling, and vascular calcification. Pharmacological agents targeting TRP channels and traditional Chinese medicine therapies demonstrate promising therapeutic potential for CKD-MBD. This article explores the role of TRP channels in CKD-MBD, from molecular mechanisms to treatment prospects, aiming to provide new insights for CKD-MBD treatment.
Keywords: Chronic kidney disease-mineral and bone disorder, Transient Receptor Potential Channels, Mineral metabolism disorders, Renal Osteodystrophy, Vascular Calcification
Received: 26 Feb 2025; Accepted: 23 Apr 2025.
Copyright: © 2025 Zhang, Xu, Hao, Wang, Xu and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chen Jiang, Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
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