ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1582694
This article is part of the Research TopicHarnessing Invasive Plant Species Into Valuable ProductsView all articles
Bioactive Lipids and Allelopathic Potential of the Invasive Plant Heracleum sosnowskyi: Insights into Its Fatty Acid Composition, Antimicrobial and Cytotoxic Effects
Provisionally accepted
Eva Borska1
Jorens Kviesis2
Anna Ramata-Stunda2
Vizma Nikolajeva2Linda Ansone-Bertina1Martins Boroduskis2
Maris Klavins1,3*- 1Department of Environmental Science, University of Latvia, Riga, Latvia, Latvia
- 2Department of Biology, University of Latvia, Riga, Latvia
- 3University of Latvia, Riga, Latvia
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Sosnowsky's hogweed (Heracleum sosnowskyi Manden) is one of the most dangerous invasive plant, notorious with presence of toxic substances. At the same time H. sosnowskyi phytochemistry from perspective of applications in pharmacology, especially lipids have not been much studied. This study aims to analyse lipids of H. sosnowskyi, especially fatty acids, their composition, metabolism patterns and biological activity. Extraction possibilities of lipids from different parts of H. sosnowskyi have been studied and besides traditional solvents, so called green solvents can be used. In lipid extracts various positional and geometric isomers of fatty acids have been found and their concentrations and profiles differ amongst plant parts. Multifactor statistical analysis demonstrates the contribution of the metabolism of fatty acids in different parts of a plant. H. sosnowskyi lipid extracts demonstrate high antimicrobial activity and cytotoxic activity against cancer cell lines and so plant biomass after eradication can be used to obtain substances with high application potential in the bio-pharma industry.
Keywords: Heracleum sosnowskyi, Invasive plants, Fatty Acids, Lipid Metabolism, Bioactivity, extraction, Antimicrobial activity, Cytoxicity
Received: 21 Mar 2025; Accepted: 18 Apr 2025.
Copyright: © 2025 Borska, Kviesis, Ramata-Stunda, Nikolajeva, Ansone-Bertina, Boroduskis and Klavins. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Maris Klavins, University of Latvia, Riga, Latvia
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