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EDITORIAL article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1580686
This article is part of the Research Topic Targeting Cellular Signalling Pathways for Disease Therapy: The Potential of Cellular Reprogramming and Protein Kinase Inhibitors View all 7 articles
Editorial -Targeting Cellular Signaling Pathways for Disease Therapy: The Potential of Cellular Reprogramming and Protein Kinase Inhibitors
Provisionally accepted- 1 University of Liverpool, Liverpool, North West England, United Kingdom
- 2 University of Aveiro, Aveiro, Aveiro, Portugal
- 3 Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil
Cellular reprogramming is particularly active during development, regeneration and cancer, when dynamic signaling pathways orchestrate cellular changes in response to input signals (1). It facilitates adaptation to exogenous pressure enabling tumor cells to adapt and survive in response to adverse microenvironments (2,3). Understanding the mechanism these adaptations happen has fueled significant advances in medical science, particularly in regenerative medicine and targeted cancer therapies (4,5). Spatialtemporal integration of cellular signaling is fundamental to effective reprogramming.Dysregulation of protein kinases is key to the pathogenesis of various pathologies, particularly cancer, dictating disease progression and inhibitors targeting this family represent pivotal tools in modern therapeutics (6). Transduction via MAPK and PI3K pathway has been extensively studied and is stablished as mediator of cancer signals (7).Molecules targeting key signaling pathways like MAPK and PI3K providing tailored therapies have already been approved for clinical applications (8,9). Despite advances, cross-communication between these pathways occurs and further understanding is needed to uncover the mechanism signaling rewiring develops (7). This research topic focuses on the rewiring signaling cascades as result of cellular reprograming and their target as therapeutic strategy consolidates recent advancements in understanding how cellular signaling pathways are modulated for therapeutic purposes. The studies included in this here provide a comprehensive overview of some aspects and developments in this field and are summarized in
Keywords: Cancer, Cell signal inhibitors, cellular reprograming, kinase, Inflammation
Received: 20 Feb 2025; Accepted: 10 Mar 2025.
Copyright: © 2025 Marensi, Oliveira and Zamoner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ariane Zamoner, Federal University of Santa Catarina, Florianopolis, 88040-970, Santa Catarina, Brazil
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