REVIEW article
Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1579609
This article is part of the Research Topic Phytochemical Interventions to Cancer View all articles
Recent advancement in the anticancer efficacy of the natural flavonoid Scutellarin: A comprehensive review
Provisionally accepted
Deena Elsori 1 Pratibha Pandey 2 Meenakshi Verma 3 Nasir Vadia 4 Roopashree R 5 Manish Vyas 6 L Lakshmi 7 Laxmidhar Maharana 8 Deepak Nathiya 9 Mohd Saeed 10 Safia Obaidur 11* Dr. Fahad Khan 12*- 1 Rabdan Academy, Abu Dhabi, United Arab Emirates
- 2 Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, India
- 3 Chandigarh University, Mohali, Punjab, India
- 4 Marwadi University, Rajkot, Gujarat, India
- 5 Jain University, Bengaluru, Karnataka, India
- 6 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India
- 7 Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India
- 8 Siksha O Anusandhan University, Bhubaneswar, Odisha, India
- 9 NIMS University, Jaipur, Rajasthan, India
- 10 University of Hail, Ha'il, Hail, Saudi Arabia
- 11 King Khalid University, Abha, Saudi Arabia
- 12 Saveetha Medical College & Hospital, Chennai, India
You have multiple emails registered with Frontiers:
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Scutellarin (SC), a natural flavonoid, has been expansively employed in treating innumerable inflammation-related diseases due to its antitumor, antiinflammatory, anticancer, and antioxidant potential. Scutellarin can inhibit significant inflammatory cell signaling pathways, comprisingPI3K/Akt, NF-κB, and MAPK, and while activating antioxidant-related pathways such as Nrf2 and ARE. Numerous reviews have outlined scutellarin's pharmacological effects and associated mechanisms in inflammation-related diseases. Several studies have elucidated the mechanisms of anticancer activity by inhibiting various signaling pathways; however, to our knowledge, none of the reviews have distinguished the anticancer potential of scutellarin based on different human cancer types. Our review outlined detailed insights about the anticancer potential of scutellarin based on cancer type in the human body. Furthermore, we have also outlined formulations, combinatorial therapies, and comprehensive mechanistic research to deliver enhanced and effective treatment options for cancer patients. This study will provide thorough and detailed insights into scutellarin, supporting its development as a promising candidate for cancer treatment.
Keywords: Scutellarin, Natural flavonoids, Cancer, formulations, Signaling Pathways
Received: 19 Feb 2025; Accepted: 12 Mar 2025.
Copyright: © 2025 Elsori, Pandey, Verma, Vadia, R, Vyas, Lakshmi, Maharana, Nathiya, Saeed, Obaidur and Khan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Safia Obaidur, King Khalid University, Abha, 61431, Saudi Arabia
Dr. Fahad Khan, Saveetha Medical College & Hospital, Chennai, India
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
