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REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1579266
This article is part of the Research TopicNutrition as a Pharmacological Approach to Metabolic Disorders and AgeingView all 7 articles
Harnessing Nutrients and Natural Agents for Sustainable Drug Development Against Ageing
Provisionally accepted
Fuan Ding1Ying Yu2
Yan Zhang3
Shibo Wei3
Jung Ho Han4Zhuo Li5Hong-Bo Jiang6
Dongryeol Ryu3
Wonyoung Park7*
Ki-Tae Ha7*Li Geng1*- 1Department of Cardiovascular Surgery, The Second Hospital of Jilin University, Jilin, China
- 2Department of Surgery, Changchun University of Chinese Medicine, Changchun, China
- 3Department of Biomedical Science and Engineering, School of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju, Gwangju, Republic of Korea
- 4Korean Medicine Application Center, Korea Institute of Oriental Medicine, Daegu, North Gyeongsang, Republic of Korea
- 5Department of Nephrology, The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China
- 6Department of Dermatology, Qingdao Women and Children’s Hospital, Qingdao University, Qingdao, Shandong, China
- 7Pusan National University, Busan, Republic of Korea
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Developing treatments for age-related diseases demands cost-effective and efficient approaches. Nutrients and natural compounds offer safer alternatives to synthetic drugs. Ageing increase the need for solutions that protect health and repair cells. Recent studies show that nutrients and natural agents reduce oxidative stress, regulate metabolism, and influence longevity-related genes. This review focuses on vitamins, minerals, antioxidants, and natural agents that improve healthspan and combat ageing. It also discusses challenges like standardization, clinical validation, and regulatory approval. Finally, emerging trends, such as personalized nutrition and advanced delivery systems, highlight the potential of these compounds for addressing ageing.
Keywords: Ageing, Nutrients, Natural agents, pharmaceuticals, Healthspan
Received: 19 Feb 2025; Accepted: 21 Mar 2025.
Copyright: © 2025 Ding, Yu, Zhang, Wei, Han, Li, Jiang, Ryu, Park, Ha and Geng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wonyoung Park, Pusan National University, Busan, Republic of Korea
Ki-Tae Ha, Pusan National University, Busan, Republic of Korea
Li Geng, Department of Cardiovascular Surgery, The Second Hospital of Jilin University, Jilin, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.