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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1575280
QingGan LiDan Capsules improved alcoholic liver injury by regulating liver lipid transport and oxidative stress in mice
Provisionally accepted
Zhiwen Fu 1,2 Jiafeng Zhou 3,4
Hongye Pan 3,4,5 Song Yang 3,4 Zhenzhen Pan 3,4 Yujia Shen 3,4 Jianbiao Yao 3,4,5*
Jiangning Hu 1*- 1 School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China
- 2 Jiangxi Conba Traditional Chinese Medicine Co.,Ltd, Shangrao, China
- 3 Zhejiang Conba Pharmaceutical Co.,Ltd, Hangzhou, China
- 4 Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Hangzhou, China
- 5 Zhejiang Key Laboratory of Major TCM Cultivation and TCM Innovation, Hangzhou, China
Background: The QingGan LiDan capsule (QGLD) consists of five traditional Chinese herbs, which have been used for hepatobiliary diseases such as jaundice. However, the effects and mechanisms by which QGLD prevent alcoholic liver diseases (ALD) remain unknown.Aim of the study: Investigate the therapeutic potential of QingGan Lidan capsule (QGLD) in alleviating alcohol-induced liver injury.Materials and Methods: Acute alcoholic liver injury model and chronic & Binge Ethanol Feeding Model (NIAAA) model were established. Mice were administered QGLD (360, 720, 1440 mg/kg) or vehicle. Liver function indicators (ALT, AST), serum lipid (TC, TG), antioxidant markers (SOD, GSH, MDA), lipid metabolism/transport genes relative expression levels, liver and ileal villus morphology were analyzed. Network pharmacology analysis was also performed to identify potential targets and pathways of QGLD.Results: QGLD reduced serum ALT, AST, hepatic TC, TG, and lipid droplet accumulation in both models. It upregulated antioxidant enzymes (SOD, GSH) and downregulated MDA. QGLD regulated the mRNA levels of genes related to the NRF2/KEAP1 pathway and lipid transport. Network pharmacology identified 221 potential targets.Conclusion: QGLD mitigates alcohol-induced liver injury by reducing lipid accumulation, regulating lipid transport and enhancing antioxidant capacity. This supports its potential application in ALD management.
Keywords: QingGan LiDan capsule, Alcoholic liver injury, Liver function, Lipid transport, Oxidative Stress
Received: 12 Feb 2025; Accepted: 17 Mar 2025.
Copyright: © 2025 Fu, Zhou, Pan, Yang, Pan, Shen, Yao and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jianbiao Yao, Zhejiang Conba Pharmaceutical Co.,Ltd, Hangzhou, China
Jiangning Hu, School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China
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