REVIEW article
Front. Pharmacol.
Sec. Renal Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1573654
This article is part of the Research TopicReviews in Renal Pharmacology: 2024View all 10 articles
Elucidating the function of Clusterin in the progression of diabetic kidney disease
Provisionally accepted
- Beijing Luhe Hospital, Capital Medical University, Beijing, China
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Diabetic kidney disease (DKD) is a common microvascular complication and the main cause of death in diabetic patients. Metabolic disorders can accelerate the occurrence and development of DKD through a variety of ways, Recent studies have found that Clusterin (Clu) levels are associated with renal dysfunction and can be used as a biomarker of renal tubular injury, while preclinical studies reveal its renoprotective function. This article reviews the molecular mechanisms of Clu in the interaction between various cells in DKD. In addition, we discuss the latest research progress of Clu in the field of DKD. This review aims to explore Clu as a potential therapeutic target for DKD and provide some guidance for future clinical treatment.
Keywords: Diabetic kidney disease, Clusterin, glucose metabolism, Lipid Metabolism, Oxidative Stress
Received: 09 Feb 2025; Accepted: 23 Apr 2025.
Copyright: © 2025 Mao, Yin, Yang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Longyan Yang, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Dong Zhao, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.