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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Inflammation Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1573135
Senecio scandens Buch.-Ham. polysaccharides exert anti-atopic dermatitis properties by modulating gut microbiota and MAPK/NF-κB pathway
Provisionally accepted- Zhejiang Chinese Medical University, Hangzhou, China
This study aims to extract the polysaccharides from Senecio scandens Buch.-Ham. (SSP) using alcohol and water extraction, and to investigate whether it can be delivered orally to treat atopic dermatitis (AD). In vivo investigations demonstrated that SSP notably improved the inflammation of mice, reducing ear swelling, scratching frequency, mast cell infiltration and epidermal thickness. Furthermore, it lowered the levels of associated inflammatory markers, raised the production of skin barrier-associated proteins, and restored gut microbial diversity, which altered the composition of bacterial communities. Experiments in vitro demonstrated that SSP could diminish the levels of inflammatory factors in the human immortal keratinocyte line (HaCaT) and suppress the MAPK/NF-κB signaling pathway. Our results suggest SSP exerts anti-AD effects and regulates the gut-skin axis in mice. The antiinflammatory mechanism involve the MAPK/NF-κB signaling pathway. It has been speculated for development into an effective drug for AD.
Keywords: Senecio scandens Buch.-Ham., Polysaccharides, atopic dermatitis, antiinflammatory, gut-skin axis
Received: 08 Feb 2025; Accepted: 03 Mar 2025.
Copyright: © 2025 Hu, Xie, Zhou, Chen, Zhou, Ding and Ye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiao-Qing Ye, Zhejiang Chinese Medical University, Hangzhou, China
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