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REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1569141
This article is part of the Research Topic Food Derived Bioactive Metabolites: Unlocking their Potential Health Benefits and Medical Potential View all 7 articles
Bioactivity and Biomedical Applications of Pomegranate Peel Extract: A Comprehensive Review
Provisionally accepted
Jinsong Du 1,2
Heming Wang 3 Lingyun Zhong 4 Shujie Wei 5 Xiaoqiang Min 2,6 Hongyan Deng 1 Xiaoyan Zhang 7 Ming Zhong 8* Yi Huang 4*- 1 Zaozhuang University, Zaozhuang, China
- 2 Shandong Coal Health School, Zaozhuang, China
- 3 Jilin University, Changchun, Hebei Province, China
- 4 Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China
- 5 Zaozhuang Municipal Hospital, Zaozhuang, China
- 6 Shandong Healthcare Group Xinwen Central Hospital, Taian, China
- 7 Shandong Healthcare Group Zaozhuang Central Hospital, Zaozhuang, China
- 8 Lanshu Cosmetics Co.Ltd., Hangzhou, China
Pomegranate peel is a by-product generated during the processing of pomegranate (Punica granatum L.) fruit, accounting for approximately 50% of the total mass of the fruit. Although pomegranate peel is usually regarded as waste, it is rich in various bioactive metabolites such as polyphenols, tannins, and flavonoids, demonstrating significant medicinal and nutritional value. In recent years, Pomegranate peel extract (PPE) has shown broad application prospects in the biomedical field due to its multiple effects, including antioxidant, anti-inflammatory, antibacterial, anti-apoptotic properties, and promotion of cell regeneration. This review consolidates the major bioactive metabolites of PPE and explores its applications in biomedical materials, including nanodrug carriers, hydrogels, and tissue engineering scaffolds. By synthesizing the existing literature, we delve into the potential value of PPE in biomedicine, the challenges currently encountered, and the future directions for research. The aim of this review is to provide a scientific basis for optimizing the utilization of PPE and to facilitate its broader application in the biomedical field.
Keywords: Pomegranate peel extract, Bioactivity, biomedical applications, Nanodrug carriers, Hydrogels, Tissue Engineering Scaffolds
Received: 31 Jan 2025; Accepted: 07 Mar 2025.
Copyright: © 2025 Du, Wang, Zhong, Wei, Min, Deng, Zhang, Zhong and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ming Zhong, Lanshu Cosmetics Co.Ltd., Hangzhou, China
Yi Huang, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, Jiangxi Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.