REVIEW article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1568109
This article is part of the Research TopicAdvances in Bioactive Compounds: Mechanisms and Therapeutic PotentialsView all 4 articles
TRPV1-target drugs for the treatment of orofacial pain
Provisionally accepted
Ana Cláudia De Macedo Andrade
Natalia Carola Molina Esquivel
Florencia Ester Goldschmied Rossel
Bruna Benso*- School of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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Orofacial pain, encompassing sensory and emotional discomfort in the facial and oral regions, is a multifaceted condition that significantly impacts patients' quality of life. This review focuses on the role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in modulating orofacial pain and new molecules targeting this receptor. TRPV1 channels act as key mediators of nociception, responding to stimuli such as temperature, pH changes, and capsaicin molecules. Recent advancements in TRPV1-targeted therapeutics, including natural, synthetic, and protein-based molecules, offer promising strategies for pain management. This review analyzed studies related to TRPV1-mediated pain inhibition, including seven clinical trials and preclinical investigations. The molecules studied in these works demonstrated pain relief, although adverse effects were reported. TRPV1-targeted molecules represent a novel avenue for developing innovative pharmacological interventions, addressing the limitations of current therapies, and improving patient outcomes in managing orofacial pain.
Keywords: pain1, orofacial pain2, Toothache3, Facial Neuralgia4, TRPV Cation Channels5, Vanilloid Receptor6. (Min.5-Max. 8)
Received: 28 Jan 2025; Accepted: 01 Apr 2025.
Copyright: © 2025 Cláudia De Macedo Andrade, Carola Molina Esquivel, Ester Goldschmied Rossel and Benso. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bruna Benso, School of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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