ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1567568
Serum 25(OH)D and plasma fatty acids on breast and gastric tumors: A cross-sectional study in Northeast China
Provisionally accepted
- Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang City, China
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Objective: A cross-sectional study was conducted in Northeast China to explore the correlation between the disease progression of solid tumors and the levels of 25 (OH) D and fatty acids.: Patients with breast and gastric tumors who met the eligibility criteria for initial treatment at the Liaoning Cancer Hospital and Research Institute between April 2020 and May 2021 were enrolled. Laboratory data were comprehensively collected, encompassing general clinical information, serum 25(OH)D levels, and plasma fatty acid levels. Logistic regression, linear regression, correlation analysis, and PLS-DA were employed to investigate the associations between tumor and the levels of 25 (OH) D and fatty acid.The levels of 25(OH)D and fatty acids in tumor patients deviated from the corresponding normal reference values. In the sample adjusted for age-related confounding, no statistically significant correlation was observed between 25(OH)D and the progression of breast tumors to malignancy (p>0.05). However, significant associations were found between 25(OH)D and TNM staging as well as molecular typing in breast malignant tumor patients (p<0.05). Plasma DPA appeared to be associated with the degree of breast tumor lesions (p < 0.05). There were notable differences in the levels of certain fatty acids among patients with different degrees of lesions and distinct tumor types. Moreover, this study revealed an association between 25(OH)D and fatty acids in tumor patients, which might vary according to tumor type.Among the population in Northeast China, the serum 25(OH)D level was found to be correlated with the TNM staging in breast cancer patients. Specifically, DPA was associated with the pathological grade of breast tumors. Moreover, significant differences were observed in fatty acid levels and their internal correlations among patients with different tumor types and varying pathological grades.
Keywords: supervision of data collection, undertook data collection, and revised the Vitamin D, Fatty Acids, Cross-sectional study, Breast Neoplasms, Gastric neoplasms
Received: 08 Feb 2025; Accepted: 18 Apr 2025.
Copyright: © 2025 Zhong, Ke and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Su Li, Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang City, China
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