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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Integrative and Regenerative Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1562264
This article is part of the Research Topic Innovative Approaches for Wound Treatment View all 7 articles
Rapid in situ formation of a double cross-linked network hydrogels for wound healing promotion
Provisionally accepted- 1 School of Pharmacy, Changchun University of Chinese Medicine, Changchun, China
- 2 Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan, Shandong Province, China
The persistent challenge lies in accelerating wound healing. Bioactive hydrogels with in situ formation properties ensure that the dressing completely adheres to the wound and isolates it from external bacteria and microorganisms in order to meet the needs of damaged skin tissue for rapid hemostasis and wound healing. In this paper, hydrogel dressing that Polyacrylamide/Sodium alginate grafted with dopamine/Gelatin grafted with glycidyl methacrylate doped with Angelica sinensis polysaccharide was prepared (PDGA). Chemical cross-linking of PAAM by adding cross-linking agent to initiate free radical polymerization and photocross-linking by free radical polymerization of GMA-GEL under UV light irradiation are two cross-linking modes to construct dual-cross-linking network of PDGA hydrogel dressing. The hydrogel remains fluid when placed in a sealed syringe and solidify rapidly by photo-cross-linking when placed on the wound. Furthermore, the hydrogel demonstrated excellent biocompatibility and hematological safety. The interaction between angelica polysaccharides and integrins on the platelet surface facilitated an augmentation in platelet adhesion, activation, and aggregation, ultimately inducing rapid coagulation of the blood within 130 s in a mouse tail vein hemorrhage model. ASP can promote tissue healing by promoting cell proliferation around wounds and accelerating the formation of new blood vessels. In a mouse skin defect model, collagen deposition, blood vessel formation, hair follicle regeneration, and granulation tissue formation were observed due to the presence of angelica polysaccharides, showing significantly superior wound healing properties when compared to Tegaderm TM film. In addition, the expression of CD31 in skin wounds treated with PDGA was significantly upregulated. Consequently, PDGA multifunctional dressings exhibit considerable potential for in vitro hemostasis and skin wound repair applications.
Keywords: Hydrogel dressing1, wound healing2, Angelica sinensis polysaccharide3, wound management4, Material sciences5
Received: 17 Jan 2025; Accepted: 03 Mar 2025.
Copyright: © 2025 Xu, Liu, Zhang, Jia and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kejin Xu, School of Pharmacy, Changchun University of Chinese Medicine, Changchun, China
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