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REVIEW article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1560715
This article is part of the Research Topic Innovations in Immunometabolic Treatment and Controlled Release Systems for Bone and Joint Disorders View all articles
Recent Advances in the Multifaceted Mechanisms of Catalpol in Treating Osteoporosis
Provisionally accepted- 1 Shandong University of Traditional Chinese Medicine, Jinan, China
- 2 Binzhou People’s Hospital, Binzhou, Shandong Province, China
Catalpol (CAT) is a landmark active ingredient in traditional Chinese medicine Rehmannia (TCT), also known as dehydroxybenzoate catalpone, which is a kind of iridoid terpene glycoside with strong antioxidant, anti-inflammatory, antitumor and other biological activities. It can exert its anti-disease effect in a variety of ways. For some patients with chronic diseases, the application of azalea alcohol in rehmannia may bring more comprehensive and long-lasting efficacy. Studies have shown that the anti-disease effect of catalpol in osteoporosis (OP) is mainly achieved through various pathways such as Wnt/β-catenin signaling pathways to promote osteogenic differentiation, and RANKL/RANK and other signaling pathways to inhibit osteoclastic differentiation. At present, there is a slight lack of analysis of the mechanism of action of catalpa alcohol in the treatment of osteoporosis, so this study comprehensively searched the literature on the mechanism of action of catalpa alcohol in the treatment of osteoporosis in various databases, and reviewed the research progress of its role and mechanism, to provide reference and theoretical basis for the further development and application of catalpol.
Keywords: Catalpol, Osteoporosis, pharmacological mechanisms, Osteogenesis, Osteoclasts
Received: 14 Jan 2025; Accepted: 17 Feb 2025.
Copyright: © 2025 Li, Mu, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Huaxin Wang, Shandong University of Traditional Chinese Medicine, Jinan, China
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