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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Translational Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1560462
This article is part of the Research Topic Pharmaceutical Biomaterials View all 30 articles
Potential effects of lipid lowering and antioxidant activity of exosomes from Phascolosoma esculenta: In vivo and in vitro Studies
Provisionally accepted
Lin Yang 1
Xue Yi 2*
Duan Meitao 2
Ahmed Mahal 3 Binbin Chen 4* Zhiqiang Zhang 2* Jungang Ren 2* Ming Chen 2*
Chen Meng 1 Moxun Xu 1*
Ahmad J Obaidullah 5 Mingyuan Liu 1*
Chen Wang 2*- 1 Jiamusi University, Jiamusi, Heilongjiang Province, China
- 2 Xiamen Medical College, Xiamen, China
- 3 Cihan University-Erbil, Erbil, Iraq
- 4 Xiamen Xianyue Hospital, Xiamen, Fujian Province, China
- 5 King Saud University, Riyadh, Riyadh, Saudi Arabia
Exosomes released from cells have shown important roles in health and disease due to their potential clinical application in therapy and diagnosis. In our study, the exosomes were extracted from Phascolosoma esculenta firstly, the lipid-lowering effect and antioxidant activity of Phascolosoma esculenta exosomes were studied by in vitro and vivo experiment. The results showed that Phascolosoma esculenta exosomes significantly reduced the lipid accumulation induced by oleic acid in high-fat HepG2 cells, and improved the levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C).Exosomes of Phascolosoma esculenta also exhibit antioxidant effects, which can reduce reactive oxygen species and malondialdehyde (MDA) levels, and increase superoxide dismutase (SOD). The exosomes of Phascolosoma esculenta have lipid-lowering effect and antioxidant activity.
Keywords: Phascolosoma esculenta, Lipid lowering, Exosomes, Hypolipidemic, antioxidant
Received: 14 Jan 2025; Accepted: 12 Feb 2025.
Copyright: © 2025 Yang, Yi, Meitao, Mahal, Chen, Zhang, Ren, Chen, Meng, Xu, Obaidullah, Liu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xue Yi, Xiamen Medical College, Xiamen, China
Binbin Chen, Xiamen Xianyue Hospital, Xiamen, 361012, Fujian Province, China
Zhiqiang Zhang, Xiamen Medical College, Xiamen, China
Jungang Ren, Xiamen Medical College, Xiamen, China
Ming Chen, Xiamen Medical College, Xiamen, China
Moxun Xu, Jiamusi University, Jiamusi, 154007, Heilongjiang Province, China
Mingyuan Liu, Jiamusi University, Jiamusi, 154007, Heilongjiang Province, China
Chen Wang, Xiamen Medical College, Xiamen, China
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