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ORIGINAL RESEARCH article

Front. Pharmacol.

Sec. Neuropharmacology

Volume 16 - 2025 | doi: 10.3389/fphar.2025.1556299

This article is part of the Research Topic Psychedelic Substances and Neurological Diseases: From Basics to Clinical Application View all 3 articles

Contextual and experiential aspects of the psychedelic experience predicting improvement in subjective well-being: Results from a Norwegian internet convenience sample

Provisionally accepted
  • 1 Indre Sogn Regional Psychiatric Clinic, Førde Hospital Trust, Førde, Norway
  • 2 Northern Regional Psychiatric Clinic, Østfold Hospital, Grålum, Østfold, Norway
  • 3 Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, Netherlands
  • 4 Centre for Psychedelic Research, Imperial College London, London, England, United Kingdom
  • 5 Section for Clinical Addiction Research, Oslo University Hospital, Oslo, Nordland, Norway
  • 6 Department of Psychology, University of Oslo, Oslo, Norway

The final, formatted version of the article will be published soon.

    Background: Interest in the therapeutic effects of classical psychedelics has risen recently. However, little epidemiological knowledge exists about the use of classical psychedelics in Scandinavian countries. Additionally, there is a limited understanding of what factors drive self-reported improvement in well-being. The aim of this study was to investigate the relationship between the use of classical psychedelics and outcomes related to subjective well-being in an adult, Norwegian-speaking sample. We examined how contextual and phenomenological variables were associated with self-reported subjective well-being. Methods: Using an anonymous internet survey, we recruited Norwegian speaking subjects who have had a memorable experience after taking a classic psychedelic substance. Data are presented by using descriptive statistics about the sample and two hierarchical regression analyses. The first regression analysis examined contextual variables, and the second examined variables related to acute phenomena during the experience. Results: The survey showed that 85 percent of the sample reported a small to large positive change in subjective well-being after their experience with classical psychedelics. Integration, ego dissolution, and emotional breakthrough had a clear, positive predictive effect on the participants' self-reported subjective well-being. Variables with lower but significant effects were the degree of challenging experiences, settings associated with nature or ceremony, and a therapeutic or seeking intention. Conclusion: The use of classical psychedelics leads to an increase in subjective well-being for the majority of the participants. This relationship seems dependent upon various experiential aspects of acute subjective drug effects. These findings should be viewed as hypothesis-generating rather than confirmatory due to the study's limitations.

    Keywords: psychedelics 6, psilocybin 3, Lysergic Acid Diethylamide (LSD), N,N-Dimethyltryptamine (DMT), Survey

    Received: 06 Jan 2025; Accepted: 21 Mar 2025.

    Copyright: © 2025 Tunstad, Kvam, Uthaug, Stewart, Andersen and Grønnerød. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Cato Grønnerød, Department of Psychology, University of Oslo, Oslo, Norway

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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