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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Respiratory Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1556185
This article is part of the Research TopicAcute and Chronic Lung Injury: Therapeutic Targets and DrugsView all 5 articles
Longitudinal relationships between serum ferritin and prognosis among severe community-acquired pneumonia patients
Provisionally accepted- 1Anhui Medical University, Hefei, China
- 2No.2 People’s Hospital of Fuyang City, Fuyang, Jiangsu Province, China
- 3Funan County People’s Hospital, Fuyang, Jiangsu Province, China
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Background ： Ferritin is one of major intracellular iron storage proteins and implicated in the pathophysiological processes of many inflammatory diseases, but the function in community-acquired pneumonia (CAP) was unclear. The purpose was to evaluate the expression of ferritin and analyze the relationship of serum ferritin with CAP.Severe CAP patients, age-and gender-matched healthy participants were recruited. Serum ferritin was detected through ELISA. Physiological characteristics were collected.Results: Serum ferritin level was significantly increased in severe CAP patients upon initial hospitalization than these in healthy participants, and decreased after therapy.Correlative analyses hinted there were obvious relationships of serum ferritin with the indicators of blood routine, liver function and inflammation. Moreover, linear and logistic regression analyses confirmed that serum ferritin level was positively related to the scores of CURB-65, CRB-65, and PSI. The poor prognosis including mechanical ventilation, vasoactive agent, ICU admission, death, and longer hospital stays were assessed in severe CAP cases during hospitalization. Multivariate logistic regression showed that serum higher ferritin level was closely linked to the poorly prognostic outcomes.There is significantly positive association between serum ferritin upon initial hospitalization with the severity and poor prognosis. Thus, serum ferritin could be as an indicator for determination severity and prognosis among CAP cases.
Keywords: ferritin, Community-acquired pneumonia, severity, prognosis, longitudinal relationship
Received: 06 Jan 2025; Accepted: 17 Apr 2025.
Copyright: © 2025 Fu, Xu, Han, Ma, Zhang, Wang, Zhang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lin Fu, Anhui Medical University, Hefei, China
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