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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1555605
This article is part of the Research Topic Herbal Medicine for the Treatment of Chronic Metabolic Diseases, Volume II View all 16 articles
Cardiorenal Protective Effects of Tanhuo Decoction in Acute Myocardial Infarction via Regulating Multi-target Inflammation and Metabolic Signaling Pathways
Provisionally accepted
Chenglong Guo 1 Tianxing Zhang 1 Lingqian He 2 Yanyan Chu 1 Xipeng Sun 1
Minyu Zhang 3 Xuexue Han 1
Yijiang Liu 4* Juexian Song 2*
Jinggang Xia 1*- 1 Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, Beijing Municipality, China
- 2 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, Beijing Municipality, China
- 3 School of Traditional Chinese Medicine, Capital Medical University, Beijing, Beijing Municipality, China
- 4 Senior Department of Hepatology, Fifth Medical Center of the PLA General Hospital, Beijing, Beijing Municipality, China
Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide, with inflammation recognized as a major contributor to its adverse outcomes. Despite advances in Western medicine, the single-target focus and significant side effects of conventional anti-inflammatory therapies limit their effectiveness in addressing residual inflammatory risk. Traditional Chinese medicine (TCM), with its multi-target and low-toxicity profile, has emerged as a promising alternative. This study investigated the therapeutic effects of Tanhuo Decoction (THD) in combination with standard Western medicine (WM) in a randomized controlled trial involving AMI patients with high inflammatory responses. Over three days of treatment, the THD+WM group demonstrated significant reductions in neutrophil counts, hs-CRP levels, as well as an improvement in creatinine clearance rate (CCR), compared to the WM group. Proteomic and network pharmacology analyses revealed that THD regulates key inflammatory pathways, downregulating pro-inflammatory proteins such as PTX3, IL-18, and TNFRSF11A, while upregulating the anti-inflammatory IL1RL2. Furthermore, THD modulated metabolic pathways related to lipid metabolism and insulin sensitivity, underscoring its potential to address comorbid conditions such as diabetes and obesity. These findings highlight the cardiorenal protection of THD through multi-target regulation of inflammation and metabolic signaling pathways, providing robust evidence for its integration into modern cardiovascular care.
Keywords: acute myocardial infarction, Tanhuo decoction, cardiorenal protection, Inflammation, Metabolism
Received: 05 Jan 2025; Accepted: 12 Mar 2025.
Copyright: © 2025 Guo, Zhang, He, Chu, Sun, Zhang, Han, Liu, Song and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yijiang Liu, Senior Department of Hepatology, Fifth Medical Center of the PLA General Hospital, Beijing, 100049, Beijing Municipality, China
Juexian Song, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, Beijing Municipality, China
Jinggang Xia, Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, Beijing Municipality, China
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