AUTHOR=Duan Yushan , Wan Xiaohong , Ma Yiming , Zhu Weihua , Yin Yue , Huang Qingqing , Yang Yuan TITLE=Application of high-dose tranexamic acid in the perioperative period: a narrative review JOURNAL=Frontiers in Pharmacology VOLUME=16 YEAR=2025 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1552511 DOI=10.3389/fphar.2025.1552511 ISSN=1663-9812