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REVIEW article
Front. Pharmacol.
Sec. Neuropharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1552295
-Nitro-2-Phenylethane: a promising phytoconstituent to modulate neuroinflammation and oxidative stress with repercussions on neurological and psychiatric disorders
Provisionally accepted
Lucas Pantoja1
Emily Christie Fonseca1
Fábio José Coelho Souza-Junior1
Brenda Costa Conceição1Sarah Viana Farias1
JOYCE KELLY R. DA SILVA1
Jose Guilherme Soares Maia1
Daniele Luz Moraes1
Pedro Iuri Castro Silva2
Rui Daniel Prediger3
JOFRE JACOB DA SILVA FREITAS 15990972
Enéas Andrade Fontes-Júnior1
Cristiane Socorro Ferraz Maia1*- 1Federal University of Pará, Belém, Brazil
- 2Universidade do Estado do Pará, Belem, Para, Brazil
- 3Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil
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Neurologic and neuropsychiatric disorders are complex, with common pathophysiological mechanisms associated with inflammation, oxidative stress, and vascular damage. These shared features have stimulated interest in bioactive compounds with neuropharmacological potential. In this regard, the 1-Nitro-2-Phenylethane (1N2PE) emerges as a promissory compound to act on the multiple via of brain disturbances. However, its neuropharmacological mechanisms of action remain largely unknown. We aim to provide a comprehensive overview of the scarce literature on the effects of 1N2PE in brain disorders to highlight the importance of further research into the mechanisms of action and its potential applications in the field of neurology and psychiatry, focusing on the anti-inflammatory and antioxidant properties. The 1N2PE exhibits neuroprotective properties, including anti-inflammatory, antioxidant, and cholinergic-enhancing effects, which together may underlie its potential therapeutic benefits for various neuropsychiatric and neurological disorders, such as depression, anxiety, seizures, and cognitive impairments. This review compiles literature on 1N2PE potential central nervous system activities, highlighting its therapeutic potential in treating behavioral and neurological disorders. Despite promising findings, further research is essential to fully understand 1N2PE as a novel therapeutic agent.
Keywords: 1-Nitro-2-phenylethane, Aniba canelilla, Neuroinflammation, Oxidative Stress, Psychiatric illness
Received: 27 Dec 2024; Accepted: 11 Apr 2025.
Copyright: © 2025 Pantoja, Fonseca, Souza-Junior, Conceição, Farias, DA SILVA, Maia, Moraes, Silva, Prediger, 1599097, Fontes-Júnior and Maia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Cristiane Socorro Ferraz Maia, Federal University of Pará, Belém, Brazil
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.