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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1551841
This article is part of the Research Topic Herbal Medicine for the Treatment of Chronic Metabolic Diseases, Volume II View all 14 articles
Comprehensive Assessment of Antioxidant, Antidiabetic, and Anti-Glycation Properties of Aqueous and Methanolic Extracts from Pistacia lentiscus L. Leaves: A Potential Natural Source for Managing Oxidative Stress and Diabetes-Related Complications
Provisionally accepted
HASNAE EL ALLAOUI 1,2,3*
Khadija Haboubi 3
Kawthar El Ahmadi 2
Mohamed Bouhrim 4* Aouatif Elabdouni 2 Bruno Eto 5
Abdelaaty Abdelaziz Shahat Hussein 6
Rashed Naji Herqash 6 Mohmed El Bestrioui 2
Zakia Zouaoui 7 Mohamed NHIRI 7- 1 Laboratory of Engineering Sciences and Applications, National School of Applied Sciences of Al Hoceima. Abdelmalek Essâadi University, Al-Hoceima, Morocco., Al Hoceima, Morocco
- 2 Laboratory of Engineering Sciences and Applications, National School of Applied Sciences of Al Hoceima. Abdelmalek Essâadi University, Al-Hoceima, Morocco., AL HOCEIMA, Morocco
- 3 Laboratory of Engineering Sciences and Applications, National School of Applied Sciences of Al Hoceima. Abdelmalek Essâadi University, AL HOCEIMA, Morocco
- 4 Laboratoire Géoressources et Environnement, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Beni Mellal, Morocco
- 5 Laboratoires TBC, Laboratory of Pharmacology, Pharmacokinetics, and Clinical Pharmacy, Faculty of Pharmaceutical and Biological Sciences, B.P.83Lille, France., Lille, France
- 6 Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
- 7 Laboratory of Biochemistry and Molecular Genetics, Faculty of Sciences and Technologies of Tangier, BP 416, 90000 Tangier, Morocco, Tanger, Morocco
This study evaluates the phenolic and flavonoid contents, as well as the antioxidant, antidiabetic, and anti-glycation properties of aqueous and methanolic extracts from Pistacia lentiscus L. leaves. The antioxidant activity was assessed using DPPH, ABTS, FRAP, and iron-chelation assays, revealing superior activity in the aqueous extract. Both extracts exhibited potent antidiabetic effects by inhibiting the digestive enzyme alpha-amylase, with IC50 values of 2,291 ± 0.002 μg/mL (aqueous) and 2,889 ± 0.002 μg/mL (methanolic). Additionally, the extracts demonstrated significant anti-glycation activity, reducing advanced glycation end-product (AGE) formation, inhibiting fructosamine levels, and protecting thiol groups, with the aqueous extract providing greater protection. These findings underscore the potential of Pistacia lentiscus L. as a natural source of bioactive compounds for managing oxidative stress and diabetes-related complications.
Keywords: Pistacia lentiscus L., Diabete mellitus, Oxidative Stress, medical herbes, Phytochemical screening, Antidiabatic activity, Antiglycation activity
Received: 26 Dec 2024; Accepted: 24 Feb 2025.
Copyright: © 2025 EL ALLAOUI, Haboubi, El Ahmadi, Bouhrim, Elabdouni, Eto, Shahat Hussein, Herqash, El Bestrioui, Zouaoui and NHIRI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
HASNAE EL ALLAOUI, Laboratory of Engineering Sciences and Applications, National School of Applied Sciences of Al Hoceima. Abdelmalek Essâadi University, Al-Hoceima, Morocco., Al Hoceima, Morocco
Mohamed Bouhrim, Laboratoire Géoressources et Environnement, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Beni Mellal, 23000, Morocco
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