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REVIEW article
Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1551115
This article is part of the Research Topic Decoding Tumor Drug Resistance: Machine Learning’s Role from Molecules to Treatment View all 3 articles
Sesquiterpene Lactones and Cancer: New Insight into Antitumor and Anti-inflammatory Effects of Parthenolide-Derived Dimethylaminomicheliolide and Micheliolide
Provisionally accepted- Department of Thyroid Head and Neck Surgery, Cancer Hospital of Dalian University of Technology. Shenyang, Liaoning 110042, China, Shenyang, Liaoning Province, China
The isolation and application of biological macromolecules (BMMs) have become central in applied science today, with these compounds serving as anticancer, antimicrobial, and anti-inflammatory agents. Parthenolide (PTL), a naturally occurring sesquiterpene lactone derived from Tanacetum parthenium (feverfew), is among the most important of these BMMs. PTL has been extensively studied for its anticancer and anti-inflammatory properties, making it a promising candidate for further research and drug development. This review summarizes the anticancer and anti-inflammatory effects of PTL and its derivatives, with a focus on Micheliolide (MCL) and Dimethylaminomicheliolide (DMAMCL). These compounds, derived from PTL, have been developed to overcome PTL’s instability in acidic and basic conditions and its low solubility. We also explore their potential in targeted and combination therapies, providing a comprehensive overview of their therapeutic mechanisms and highlighting their significance in future cancer treatment strategies.
Keywords: Parthenolide, Micheliolide, Dimethylaminomicheliolide, antiinflammatory, anti-cancer
Received: 24 Dec 2024; Accepted: 28 Jan 2025.
Copyright: © 2025 Li, Xin and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hongwei Liu, Department of Thyroid Head and Neck Surgery, Cancer Hospital of Dalian University of Technology. Shenyang, Liaoning 110042, China, Shenyang, Liaoning Province, China
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