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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Pharmacology of Infectious Diseases
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1550378
This article is part of the Research Topic Therapeutic and Protective Approaches to Gastrointestinal Tract Infections View all articles
Association between statin administration and Clostridium difficile-induced enteritis: A retrospective analysis of the MIMIC-IV database
Provisionally accepted- Ningbo No.2 hospital, Ningbo, China
Background: Existing research suggests that using statins may reduce the incidence of enteritis caused by Clostridium difficile and improve the prognosis of patients. This study aimed to explore the relation between C. difficile-induced enteritis (CDE) and statin use.Methods: Data were collected from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. Multivariate logistic regression analysis was employed to assess the impact of statin use on CDE incidence in patients in intensive care units (ICUs) and its effect on in-hospital mortality among them. The research findings were validated by performing propensity score matching (PSM), inverse probability of treatment weighting (IPTW), and subgroup analyses. Results: The study enrolled the data of 51,978 individuals to assess the effect of statin usage on the occurrence of CDE in patients admitted to the ICU. The results indicate that statins can decrease the prevalence of CDE in patients in ICU (odds ratio (OR): 0.758, 95% confidence interval (CI): 0.666–0.873, P < 0.05), which was further confirmed through PSM (OR: 0.760, 95% CI: 0.661–0.873, P < 0.05) and IPTW (OR: 0.818, 95% CI: 0.754–0.888, P < 0.05) analyses. For most subgroups, statins’ favorable effect in reducing CDE remained constant. A total of 1,208 patients were included in the study to evaluate whether statins could lower the risk of death in patients in ICU with enteritis caused by C. difficile. Statins did not reduce in-hospital mortality of patients in ICU with CDE (OR: 0.911, 95% CI: 0.667–1.235, P = 0.553). The results were validated following PSM (OR: 0.877, 95% CI: 0.599–1.282, P = 0.499) and IPTW (OR: 0.781, 95% CI: 0.632–1.062, P = 0.071) analyses, and all subgroups demonstrated consistent results.Conclusion: Statin administration can reduce the incidence of CDE in patients in the ICU; however, it does not decrease the in-hospital mortality rate for individuals with CDE.
Keywords: Clostridium difficile-induced enteritis, MIMIC-IV database, Intensive Care Unit, Incidence, In-hospital mortality
Received: 23 Dec 2024; Accepted: 30 Jan 2025.
Copyright: © 2025 Wang, Liu, Wang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhaojun Xu, Ningbo No.2 hospital, Ningbo, China
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