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REVIEW article
Front. Pharmacol.
Sec. Integrative and Regenerative Pharmacology
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1548837
This article is part of the Research Topic Innovative Approaches for Wound Treatment View all 4 articles
Compliant Immune Response of Silk-based Biomaterials Broadens Application in Wound Treatment
Provisionally accepted- 1 Southwest University, Chongqing, Chongqing Municipality, China
- 2 903 Hospital of Joint Logistic Support Force of The People's Liberation Army, Hangzhou, Jiangsu Province, China
The unique properties of sericin and silk fibroin (SF) favor their widespread application in biopharmaceuticals, particularly in wound treatment and bone repair. The immune response directly influences wound healing cycle, and the extensive immunomodulatory functions of silk-based nanoparticles and hydrogels have attracted wide attention. However, different silk-processing methods may trigger intense immune system resistance after implantation into the body. In this review, we elaborate on the inflammation and immune responses caused by the implantation of sericin and SF and also explore their anti-inflammatory properties and immune regulatory functions. More importantly, we describe the latest research progress in enhancing the immunotherapeutic and anti-inflammatory effects of composite materials prepared from silk from a mechanistic perspective. This review will provide a useful reference for using the correct processes to exploit silk-based biomaterials in different wound treatments.
Keywords: biopharmaceuticals, Nanomedicine, Sericin, Silk fibroin (SF), Wound treatment
Received: 20 Dec 2024; Accepted: 23 Jan 2025.
Copyright: © 2025 Tian, Chen and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ping Zhao, Southwest University, Chongqing, 400715, Chongqing Municipality, China
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