CASE REPORT article
Front. Pharmacol.
Sec. Neuropharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1547236
Case Report: Linezolid-associated Toxic Optic Neuropathy in Patients with Pulmonary Tuberculosis: Case series and Mini Review
Provisionally accepted
- School of Medicine, Pusan National University, Busan, Republic of Korea
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Linezolid is a useful second-line medication for the treatment of tuberculosis that is resistant to multiple drugs. However, long-term therapy can cause side effects, such as optic neuropathy. We describe three cases of progressive painless bilateral visual loss in patients taking long-term linezolid therapy for multidrug-resistant and extensively drug-resistant tuberculosis. We reviewed the literatures and identified 58 cases of linezolid optic neuropathy. Discontinuation of linezolid resulted in a marked improvement in vision, however it was not complete in all patients. Knowledge of visual monitoring of patients undergoing long-term linezolid therapy is important for physicians and ophthalmologists.
Keywords: case report, Extensive drug resistance, linezolid, Muti-drug registance, Toxic optic neuropathy, Tuberculosis
Received: 19 Dec 2024; Accepted: 21 Apr 2025.
Copyright: © 2025 Yun, Kim, Han, Choi and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Su Jin Kim, School of Medicine, Pusan National University, Busan, Republic of Korea
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