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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1546119
Cassiae Semen Extract Ameliorates Hyperlipidemia in Rats by Modulating Lipid Metabolism and FcγR-Mediated Immune Regulation
Provisionally accepted
Mingyue Lv1Yannan Zheng1Man Yuan1Errui Zhang1Min Zheng1Guangyao Liu1
Min Zheng1
Hongxi Xu2*
Weiliang Gu1*- 1Shanghai University of Traditional Chinese Medicine, Shanghai, China
- 2Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, Beijing Municipality, China
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This study investigated the effects of Cassiae Semen Extract (CSE) on hyperlipidemia in rats and explored its potential mechanisms. A hyperlipidemia model was induced in rats using a high-fat diet (HFD), and serum, liver, and fecal samples were analyzed after CSE intervention. The results showed that CSE effectively alleviated biochemical imbalances and tissue damage induced by the HFD. 16S rRNA sequencing revealed that CSE improved gut microbiota dysbiosis and increased microbiota abundance. Pathological analysis demonstrated that CSE reduced hepatic lipid accumulation, mitigating liver damage. KEGG pathway analysis suggested that the beneficial effects of CSE on hyperlipidemia may involve Fc gamma receptor (FcγR)-mediated phagocytosis, with immune activation influencing lipid homeostasis and liver inflammation. Western blot analysis further indicated that CSE may regulate lipid metabolism via Sterol Regulatory Element-Binding Protein-1c (SREBP-1c) and Peroxisome Proliferator-Activated Receptor Alpha (PPARα), while reducing hepatic inflammation through the MAPK signaling pathway. These findings suggest that CSE may ameliorate hyperlipidemia in rats by modulating gut microbiota disorders, lipid metabolism and FcγR-mediated immune regulation, providing a potential therapeutic approach for diseases associated with metabolic dysfunction and inflammation.
Keywords: Cassiae semen extract, Hyperlipidemia, Gut Microbiota, Lipid Metabolism, Fc gamma R, high-fat diet, Inflammation
Received: 17 Dec 2024; Accepted: 10 Apr 2025.
Copyright: © 2025 Lv, Zheng, Yuan, Zhang, Zheng, Liu, Zheng, Xu and Gu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hongxi Xu, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, Beijing Municipality, China
Weiliang Gu, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.