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REVIEW article
Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1545654
This article is part of the Research Topic Enhancing Cancer Therapy: Integrating Plant-Derived Bioactives with Chemotherapy through Traditional Knowledge and Modern Advances View all articles
Asiatic Acid in Anticancer Effects: Emerging Roles and Mechanisms
Provisionally accepted- 1 College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
- 2 Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
- 3 Dalian Medical University, Dalian, Liaoning, China
Medicinal plants are crucial in the comprehensive treatment of anti-tumor with the advantages of high efficacy, low toxicity, multiple pathways and multitargets synergy, leading to be a focal point of study for many oncologists. Identifying effective monomer components with anti-tumor properties from medicinal plants has long been a crucial focus in the study and development of traditional Chinese medicine. This endeavor has significant research value and promising possibilities for further advancement. Asiatic Acid (AA), a pentacyclic triterpenoid derived from Centella asiatica (L.) Urb, is used in traditional Chinese medicine and has been shown to have anti-tumor properties on a range of tumor types. The present study assessed the anti-tumor properties of AA from five different perspectives: inhibiting proliferation, inducing apoptosis, inhibiting invasion and metastasis, regulating cell autophagy, enhancing the resistance of tumor cells to drugs, and minimizing adverse side effects.
Keywords: Asiatic acid, tumor, antitumor activity, tumor cells, invasion and metastasis
Received: 15 Dec 2024; Accepted: 31 Jan 2025.
Copyright: © 2025 Chen, Zhang, Zhang, Liu, Feng and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rong Chen, College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
Yanan Zhang, College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
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