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REVIEW article
Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1543697
Berberine and its Derivatives: Mechanisms of Action in Myocardial Vascular Endothelial Injury -A Review
Provisionally accepted
Wenhui Zhang 1
Siyi Guo 2
Jinjin Dou 3*
Xiwu Zhang 4*
Fan Shi 1 Chun Zhang 1 Huxiao Zhang 1 Xiaodong Lan 1 Yi Su 1- 1 Heilongjiang University of Chinese Medicine, Harbin, China
- 2 Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
- 3 Fourth Affiliated Hospital of Heilongjiang University of traditional Chinese Medicine, Harbin, Heilongjiang Province, China
- 4 Experimental Teaching and Partical Training Center, Heilongjiang University of Chinese Medicine, Harbin, Jilin Province, China
Myocardial vascular endothelial injury serves as a crucial inducer of cardiovascular diseases. Mechanisms such as endoplasmic reticulum stress, apoptosis, inflammation, oxidative stress, autophagy, platelet dysfunction, and gut microbiota imbalance are intimately linked to this condition. Berberine and its derivatives have demonstrated potential in modulating these mechanisms. This article reviews the pathogenesis of endothelial injury in myocardial vessels, the pharmacological effects of berberine and its derivatives, particularly their interactions with targets implicated in vascular endothelial injury. Furthermore, it discusses clinical applications, methods to enhance bioavailability, and toxicity concerns, aiming to lay a foundation for the development of BBR as a therapeutic agent for cardiovascular diseases.
Keywords: Berberine, Myocardial vascular endothelial injury, mechanism of action, Cardiovascular Diseases, Cardioprotection
Received: 11 Dec 2024; Accepted: 31 Jan 2025.
Copyright: © 2025 Zhang, Guo, Dou, Zhang, Shi, Zhang, Zhang, Lan and Su. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jinjin Dou, Fourth Affiliated Hospital of Heilongjiang University of traditional Chinese Medicine, Harbin, 150070, Heilongjiang Province, China
Xiwu Zhang, Experimental Teaching and Partical Training Center, Heilongjiang University of Chinese Medicine, Harbin, 150040, Jilin Province, China
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