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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Neuropharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1538857
This article is part of the Research Topic New Strategies for Spinal Cord Injury and Immunotherapy Targeting Novel Programmed Death Pathways View all articles
Teriparatide mitigates oxidative stress following Spinal Cord Injury and enhances neurological recovery via the Nrf2/HO-1 signaling pathway
Provisionally accepted
Moliang Xiong 1,2
Gangtong Ai 3 Yun Feng 1,2 Caiguang Luo 1,2 Liang Deng 1,2 Jia Guo 1,2
Qiang Xiao 1,2*- 1 Jiangxi Provincial People's Hospital, Nanchang, China
- 2 The First Affiliated Hospital of Nanchang Medical College, Nanchang, China
- 3 Department of Orthopedics, Shangrao People's Hospital, Shangrao, China
Spinal Cord Injury(SCI) represents a devastating form of central nervous system trauma, where oxidative stress plays a critical role in the ensuing pathology.Targeting oxidative stress presents a viable therapeutic avenue. Teriparatide, a synthetic analog of parathyroid hormone, is conventionally utilized for osteoporosis and bone defect management. Emerging evidence suggests teriparatide's potential in modulating oxidative stress in ischemic stroke, yet its efficacy in SCI remains underexplored. In our study, teriparatide was administered to rats with SCI, yielding two key findings. Firstly, teriparatide treatment significantly enhanced motor function recovery post-SCI. Secondly, teriparatide upregulated Nrf2 expression, which subsequently increased the production of the antioxidant proteins HO-1 and SOD2, reduced malondialdehyde (MDA) levels in spinal tissues, and boosted glutathione peroxidase (GSH-PX) activity. These results suggest that teriparatide
Keywords: spinal cord injury, Nrf2, Teriparatide, Oxidat ive stress, MDA
Received: 03 Dec 2024; Accepted: 03 Mar 2025.
Copyright: © 2025 Xiong, Ai, Feng, Luo, Deng, Guo and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qiang Xiao, Jiangxi Provincial People's Hospital, Nanchang, China
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