The final, formatted version of the article will be published soon.
REVIEW article
Front. Pharmacol.
Sec. Renal Pharmacology
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1537749
Research Progress of Hypoxia-Inducible Factor-1α and Zinc in the Mechanism of Diabetic Kidney Disease
Provisionally accepted- Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
Diabetic kidney disease is one of the common complications in diabetic patients and has gradually become an important pathogenic factor in chronic kidney disease. Therefore, studying the mechanisms of its occurrence and development is of great significance for the prevention and treatment of diabetic kidney disease. Some researchers have pointed out that there is a phenomenon of hypoxia in diabetic kidney tissue and believe that hypoxia-inducible factor-1α is closely related to the occurrence and progression of diabetic kidney disease. Additionally, the homeostasis of zinc plays a key role in the body's adaptation to hypoxic environments. However, the specific relationship among these three factors remains unclear. This article provides a detailed review of the multiple roles of hypoxia-inducible factor-1α in the pathogenesis of diabetic kidney disease, including: regulating angiogenesis, increasing the expression of erythropoietin, modulating oxidative stress through the PI3K/AKT and HIF-1α/HO-1 pathways, promoting inflammatory cell infiltration and the release of inflammatory factors to induce inflammatory responses, facilitating epithelial-mesenchymal transition, pathological angiogenesis, and promoting the release of fibrotic factors, ultimately leading to renal fibrosis. Furthermore, HIF-1α also participates in the occurrence and development of diabetic kidney disease through mechanisms such as regulating apoptosis, inducing mitochondrial autophagy, and vascular calcification. At the same time, this article clarifies the regulatory role of the trace element zinc on hypoxia-inducible factor-1α in diabetic kidney disease. This article provides references and insights for further research on the pathogenesis and progression of diabetic kidney disease.
Keywords: Hypoxia inducible factor-1α, Zinc, diabetic kidney disease, diabetic nephropathy, HIF- 1 α
Received: 01 Dec 2024; Accepted: 16 Jan 2025.
Copyright: © 2025 Qin, NIE, Hui, Chen, Hu, Shi, li and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
xuejun Hui, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
fei Chen, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
xingbao Hu, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
wenjiao Shi, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
bing li, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
Manyu Luo, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.