The final, formatted version of the article will be published soon.
REVIEW article
Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1537695
Gelatin-based biomaterials as a delivery strategy for osteosarcoma treatment
Provisionally accepted- 1 First Affiliated Hospital of Jilin University, Changchun, China
- 2 The First Affiliated Hospital of Shandong First Medical University, Bone、joint and sports medicine, Jinan, Shandong Province, China
- 3 Department of Obstetrics, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China
Osteosarcoma is the most common primary malignant bone tumor. Although surgery and chemoradiotherapy have made some progress in the treatment of osteosarcoma. However, the high recurrence and metastasis rate of osteosarcoma and bone defects caused by surgery are still the main problems faced by osteosarcoma. Gelatin has excellent biocompatibility and biodegradability, and has made phased progress in tumor treatment. In the treatment of osteosarcoma, gelatin-based biomaterials can be used in delivery strategies to enhance the anti-tumor activity of osteosarcoma and can improve the appropriate compressive strength to improve the bone defects faced after surgery. At present, gelatin-based hydrogels, gelatin scaffolds, and gelatin-based nanoparticles have been reported in preclinical studies. In this article, we introduce the application of gelatin-based biomaterials in the treatment of osteosarcoma, and summarize and look forward to them.
Keywords: Osteosarcoma, Gelatin, Osteoblasts, Osteoclasts, Bone defects
Received: 01 Dec 2024; Accepted: 13 Jan 2025.
Copyright: © 2025 Qifan, Chen, Liu and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xingpeng Chen, The First Affiliated Hospital of Shandong First Medical University, Bone、joint and sports medicine, Jinan, Shandong Province, China
Jing Liu, Department of Obstetrics, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China
Yeteng He, The First Affiliated Hospital of Shandong First Medical University, Bone、joint and sports medicine, Jinan, Shandong Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.