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REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1534798
This article is part of the Research Topic Food Derived Bioactive Metabolites: Unlocking their Potential Health Benefits and Medical Potential View all 5 articles
Formononetin: A review of its source, pharmacology, drug combination, tox icity, derivatives, and drug delivery systems
Provisionally accepted
min Jin 1* linfang wei 2*
Jianhua Wang 3
Yuehong Shen 4 Fan Zhao 4* Lei Gao 4* Qianying Gao 4* Yifei Ma 4* Yongyan Sun 4* Ying Lin 4*
Guanjie Ji 5
Pingping Cai 6* Rugen Yan 4*- 1 Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
- 2 Third Clinical Medical School, Nanjing University of Chinese Medicine, Yancheng, China
- 3 Affliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
- 4 College of Traditional Chinese Medicine School of Integrative Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
- 5 Weifang Traditional Chinese Hospital, Weifang, China
- 6 Department of Traditional Chinese Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, jinan, China
Formononetin (FMN) is a common natural metabolite that can be extracted and isolated from some common botanical drugs. In recent years, FMN has garnered increasing attention due to its beneficial biological activities. In this paper, we systematically summarize the sources of FMN and provide a comprehensive review of its pharmacological activities and molecular mechanisms, coadministration, toxicity, derivatives, and drug delivery systems in the last five years. The study results found that FMN has a wide range of pharmacological activities in neurological disorders, organ damage and cancer, showing great potential for clinical application and broad prospects.Researchers are exploring various types of delivery systems, including nanoparticle carriers, ligand modifications and polymer microspheres. These advanced delivery systems can enhance the stability of FMN, prolong its release time in vivo, and improve targeting, thereby optimizing its therapeutic efficacy and reducing side effects, and greatly improving its bioavailability. In conclusion, FMN is a natural metabolite with considerable research value, and its diverse biological activities make it a promising candidate for drug development and medical research.
Keywords: Formononetin, Pharmacology, drug combination, Toxicity, derivatives, Drug Delivery Systems
Received: 26 Nov 2024; Accepted: 31 Jan 2025.
Copyright: © 2025 Jin, wei, Wang, Shen, Zhao, Gao, Gao, Ma, Sun, Lin, Ji, Cai and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
min Jin, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong Province, China
linfang wei, Third Clinical Medical School, Nanjing University of Chinese Medicine, Yancheng, 211166, China
Fan Zhao, College of Traditional Chinese Medicine School of Integrative Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
Lei Gao, College of Traditional Chinese Medicine School of Integrative Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
Qianying Gao, College of Traditional Chinese Medicine School of Integrative Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
Yifei Ma, College of Traditional Chinese Medicine School of Integrative Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
Yongyan Sun, College of Traditional Chinese Medicine School of Integrative Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
Ying Lin, College of Traditional Chinese Medicine School of Integrative Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
Pingping Cai, Department of Traditional Chinese Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, jinan, China
Rugen Yan, College of Traditional Chinese Medicine School of Integrative Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
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