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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1534748
Unveiling the processing mechanism of Hezi-decoction-processed Tiebangchui: A synthesis approach using UPLC-Q-TOF-MS-based metabolomics and DESI-MSI
Provisionally accepted
Zhen Zhou *
Gao Huimin 
Zhaoqing Pei 
Meng-Xiang Sha 
Congying Li 
Yi Zhang Jin-Song Su 
Yue Liu 
Xianli Meng - Chengdu University of Traditional Chinese Medicine, Chengdu, China
DDAs diester-diterpenoid alkaloids DESI-MSI desorption electrospray ionization mass spectrometry imaging Hezi Terminalia chebula Retz. HDI high-definition imaging HPLC high-performance liquid chromatography MDAs monoester-diterpenoid alkaloids NDAs non-esterified diterpene alkaloids OPLS-DA orthogonal partial least-square discriminant analysis PCA principal component analysis PLS-DA partial least-square discriminant analysis RSD relative standard deviation TBC Aconitum pendulum Busch UPLC ultra-high-performance liquid chromatography UPLC-Q-TOF-MS ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry VIP variable importance for projection
Keywords: Tiebangchui, UPLC-Q-ToF-MS, Hezi-decoction-processed, Toxicity attenuation, DESI-MSI
Received: 26 Nov 2024; Accepted: 27 Feb 2025.
Copyright: © 2025 Zhou, Huimin, Pei, Sha, Li, Zhang, Su, Liu and Meng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhen Zhou, Chengdu University of Traditional Chinese Medicine, Chengdu, China
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