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REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1534634
This article is part of the Research Topic Herbal Medicine for the Treatment of Chronic Metabolic Diseases, Volume II View all 10 articles

Natural products targeting AMPK signaling pathway therapy, Diabetes mellitus and its complications

Provisionally accepted
Li Min Li Min 1Lu Ding Lu Ding 2Liyuan Cao Liyuan Cao 1Zepeng Zhang Zepeng Zhang 2Xueyan Li Xueyan Li 1Zirui Li Zirui Li 1Qinjing Xia Qinjing Xia 1Kai Yin Kai Yin 1Siyu Song Siyu Song 1Zihan Wang Zihan Wang 1Haijian Du Haijian Du 1Daqing Zh ao Daqing Zh ao 1*Xiangyan Li Xiangyan Li 1*Zeyu Wang Zeyu Wang 2*
  • 1 Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, China
  • 2 Research Center of Traditional Chinese Medicine, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China

The final, formatted version of the article will be published soon.

    Diabetes mellitus (DM) ranks among the most prevalent chronic metabolic diseases, characterized primarily by a persistent elevation in blood glucose levels. This condition typically stems from either insufficient insulin secretion or a functional defect in the insulin itself. Clinically, diabetes is primarily classified into type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), with T2DM comprising nearly 90% of all diagnosed cases. Notably, the global incidence of T2DM has surged dramatically over recent decades. The adenylate-activated protein kinase (AMPK) signaling pathway is crucial in regulating cellular energy metabolism, marking it as a significant therapeutic target for diabetes and related complications.Natural products, characterized by their diverse origins, multifaceted bioactivities, and relative safety, hold considerable promise in modulating the AMPK pathway. This review article explores the advances in research on natural products that target the AMPK signaling pathway, aiming to inform the development of innovative antidiabetic therapies.

    Keywords: AMPK, Natural Products, type 2 diabetes, complications, Mechanism

    Received: 26 Nov 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 Min, Ding, Cao, Zhang, Li, Li, Xia, Yin, Song, Wang, Du, Zh ao, Li and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Daqing Zh ao, Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, Jilin Province, China
    Xiangyan Li, Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, Jilin Province, China
    Zeyu Wang, Research Center of Traditional Chinese Medicine, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, 130021, Jilin Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.