Xin-da Wang
1
Chaoya Li
1*
Jia Hu
1
Fen Cao
2
Zhongzheng Wen
1*
Jun Liu
2*The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1534479
This article is part of the Research Topic Clinical Pharmacist Service Promotes the Improvement of Medical Quality Volume II View all 36 articles
Hemoglobin-to-Red Blood Cell Distribution Width Ratio as a Protective Factor Against Coronary Artery Disease: A Cross-Sectional Analysis of NHANES (2011-2018
Provisionally accepted- 1 Chengdu First People’s Hospital, Chengdu, Sichuan Province, China
- 2 hunan university of medicine general hospital, Huaihua, China
Background: Coronary artery disease (CAD) is the leading cause of death worldwide, and inflammation is a significant factor in its development. While the hemoglobin-to-red blood cell distribution width ratio (HRR), an indicator of inflammation, has been linked to various diseases, its association with CAD is not well established.We conducted an analysis using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018. After excluding participants due to age, missing data, and potential confounding factors, 6,881 individuals were included in our study. CAD was identified through self-reported questionnaires, and HRR was determined from laboratory measurements. We controlled for factors such as hypertension, waist circumference, systolic blood pressure, fasting plasma glucose, and others in our logistic regression analysis to explore the relationship between HRR and CAD.We found that higher HRR levels were associated with a lower risk of CAD. In our fully adjusted model, the odds ratios for CAD for the second, third, and fourth quartiles of HRR were 0.38, 0.42, and 0.51, respectively, compared to the first quartile (P<0.001). An increase in HRR by one unit was associated with a 49% decrease in the likelihood of CAD. Furthermore, linear regression models indicated a 74% reduction in CAD risk for each one-unit increase in HRR (P=0.0002). There was a notable threshold at HRR 1.02; beyond this point, each unit increase in HRR was associated with a 91% decrease in CAD odds. This suggests that for individuals with an HRR above 1.02, strategies to increase body water content and reduce blood viscosity could potentially lower their risk of developing CAD.Our study revealed an inverse linear relationship between HRR and CAD risk, indicating that HRR may serve as a protective factor against CAD.
Keywords: Coronary Artery Disease, Hemoglobin-to-red blood cell distribution width ratio, Inflammation, NHANES, Cross-sectional study
Received: 26 Nov 2024; Accepted: 07 Jan 2025.
Copyright: © 2025 Wang, Li, Hu, Cao, Zhu, Zhu, Wen and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chaoya Li, Chengdu First People’s Hospital, Chengdu, Sichuan Province, China
Li Zhu, Chengdu First People’s Hospital, Chengdu, Sichuan Province, China
Yongzhi Zhu, hunan university of medicine general hospital, Huaihua, China
Zhongzheng Wen, Chengdu First People’s Hospital, Chengdu, Sichuan Province, China
Jun Liu, hunan university of medicine general hospital, Huaihua, China
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