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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1534048
Ocular Pharmacokinetics of Intravitreal Conbercept in a Rabbit Model with Retinal Scatter Laser Photocogulation
Provisionally accepted- 1 Medical school of Chinese PLA, Beijing, China
- 2 Senior Department of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital, Beijing, China
Objectives: To evaluate the ocular pharmacokinetics of intravitreal conbercept after retinal scatter laser photocogulation. Methods: Thirty male Chinchilla rabbits (60 eyes) were used. Control and photocoagulated animals received single bilateral intravitreal injections of conbercapt. Ocular tissues were collected and quantified for drug concentration using ELISA assays. Statistical analysis was performed to compare the pharmacokinetic parameters between the control and photocoagulated eyes.Results: Conbercept concentrations were higher in control rabbits than photocoagulated rabbits, and reached peak values in all the ocular tissues 1d after IVT dosing. Terminal t1/2 in vitreous (4.36 days), aqueous humor (4.19 days), retina (3.94 days) and choroid-RPE(3.84 days) in control eyes were longer than that in vitreous (3.82 days), aqueous humor (3.69 days), retina (3.65 days) and choroid-RPE(3.58 days) in photocoagulated eyes, respectively. Conbercept exposure as assessed by AUC0-t was lower in photocoagulated than control animals in all four ocular matrices (P<0.01). In photocoagulated eyes, clearance and volume of distribution were greater than control eyes, while mean residence times were shorter in all four matrices. Conclusions: Retinal scatter laser photocogulation shortly before single intravitreal injection of conbercept had a higher drug clearance and shorter half-life, resulting in less exposure in ocular compared to the non-photocoagulation. The distinct ocular pharmacokinetics of intravitreal conbercept in a rabbit model with retinal scatter laser photocogulation may enlighten further studies to investigate optimal order of combination of photocoagulation and anti-VEGF agent.
Keywords: Ocular pharmacokinetics, Photocoagulation, conbercept, anti-vegf, rabbit
Received: 25 Nov 2024; Accepted: 28 Feb 2025.
Copyright: © 2025 Chen, Liu, Zhang and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Houbin Huang, Senior Department of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.