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SYSTEMATIC REVIEW article

Front. Pharmacol.
Sec. Pharmacoepidemiology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1533984
This article is part of the Research Topic Pharmacoepidemiology in Chronic Diseases View all 5 articles

Global Bibliometric Analysis of Traditional Chinese Medicine Regulating Gut Microbiota in the Treatment of Diabetes from 2004 to 2024

Provisionally accepted
Jieling Liang Jieling Liang 1*Xiaojuan Lin Xiaojuan Lin 2Xin Liao Xin Liao 2Xi Chen Xi Chen 1Ying Zhou Ying Zhou 1Lin Zhang Lin Zhang 2Yunyun Qin Yunyun Qin 2Haoru Meng Haoru Meng 2Zhongwen Feng Zhongwen Feng 2
  • 1 Guilin Hospital of the Second Xiangya Hospital CSU, Guilin, China
  • 2 People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Region, China

The final, formatted version of the article will be published soon.

    The therapeutic efficacy of Traditional Chinese Medicine (TCM) in modulating gut microbiota for diabetes treatment has garnered increasing scholarly attention. This study aims to meticulously examine current research trajectories and focal areas from 2004 to 2024, providing a foundational framework for future inquiries.Methods: A comprehensive search of documents published between 2004 and 2024 was conducted using the Web of Science database. The resulting data were analyzed and visualized using R software, VOSviewer, and CiteSpace.The study included a total of 751 documents. From 2004 to 2022, the number of annual publications showed a continuous upward trend (2004: n=1 to 2022: n=159), and the number of publications in 2023(n=141) decreased slightly from the previous year. China emerged as the leading country in terms of article publications(n=430). Additionally, the United States played a prominent role in international research collaborations. Frontiers in Pharmacology(n=31) was the most frequently published journal, while Nature(n=1147) achieved the highest citation count. Key identified keywords included obesity, insulin resistance, inflammation, and oxidative stress. 2 Conclusion: Three key research focuses in this domain include: the therapeutic effects of active constituents in TCM on diabetes via gut microbiota modulation, the underlying mechanisms through which TCM influences gut microbiota in diabetes management, and the targeted regulation of specific gut bacterial populations by TCM in the treatment of diabetes.

    Keywords: Traditional Chinese Medicine, diabetes, Gut Microbiota, Active constituents, Mechanism

    Received: 25 Nov 2024; Accepted: 07 Jan 2025.

    Copyright: © 2025 Liang, Lin, Liao, Chen, Zhou, Zhang, Qin, Meng and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jieling Liang, Guilin Hospital of the Second Xiangya Hospital CSU, Guilin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.