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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1533709

Association between hyperuricemia and all-cause mortality in people taken Statins: a retrospective cohort study

Provisionally accepted
Bin Zhu Bin Zhu 1*Zijun He Zijun He 2Mingfen Wu Mingfen Wu 1Jiping Huo Jiping Huo 1Zhigang Zhao Zhigang Zhao 1Wei Guo Wei Guo 3Li Yang Li Yang 1
  • 1 Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  • 2 Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing Municipality, China
  • 3 Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Background: Statins are one of the most widely prescribed medicines in clinical. Its benefits have extended beyond cardiovascular applications to reduce serum uric acid levels. This study aims to investigate the associations of hyperuricemia with the risk of all-cause mortality among individuals taken Statins.Method: A retrospective cohort study was performed using data from the National Health and Nutrition Examination Survey (NHANES) database between 2005 and 2018. The weighted Cox proportional hazards models were used to investigate the association between hyperuricemia and all cause-mortality.Results: A total of 1959 participants were enrolled for analysis. Of them 1429 were with normal uric acid level, and 529 people were with hyperuricemia. After 12 years follow up, there were 267 participants die of all-cause mortality in non-hyperuricemia and 136 died in the hyperuricemia group. Nearly 32.49% of people taken more than 5 kinds of medicines in the non-hyperuricemia group and 42.05% in the hyperuricemia. Of those taken Statins, we had found that serum uric acid (SUA) level was significantly correlated with the all-cause mortality even adjusted for confounding factors (HR=1.13, 95% CI:1.02-1.24, p=0.0161); Additionally, compared with non-hyperuricemia participant, hyperuricemia caused significant increases of all-cause mortality in three models (HR=1.51, 95% CI:1.16-1.96, P=0.0023).Conclusion: Although Statins have been found with uric acid lower effect, hyperuricemia is still significantly associated with the all-cause mortality in people taken Statins. Those taken Statins and with hyperuricemia should pay special attention to their SUA level.

    Keywords: Statin (HMG-CoA reductase inhibitor), Hyperuricemia, all-cause mortality, NHANES, Serum uric acid

    Received: 24 Nov 2024; Accepted: 20 Jan 2025.

    Copyright: © 2025 Zhu, He, Wu, Huo, Zhao, Guo and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bin Zhu, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.