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REVIEW article
Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1533628
This article is part of the Research Topic Exercise Preconditioning in Ischemia-Reperfusion Injury View all articles
Understanding the Complex Role of Exosomes in Intestinal Ischemia-Reperfusion Injury: From Pathogenesis to Protection
Provisionally accepted- 1 Zigong Fourth People's Hospital, Zigong, Sichuan, China
- 2 Fushun County People's Hospital, Fushun, Sichuan, China
- 3 The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
Extracellular vesicles, which are predominantly classified into ectosomes and exosomes, are released by all cells under both physiological conditions and in response to acquired pathological states. Exosomes demonstrate multifaceted functions: they regulate cellular homeostasis through the elimination of redundant or detrimental intracellular components, function as mediators in intercellular signaling pathways, and serve as potential vectors for both diagnostic and therapeutic applications. Intestinal ischemia-reperfusion injury (IRI), a prevalent form of tissue and organ injury in surgical settings, has been extensively investigated. Emerging evidence indicates a crucial relationship between exosomes and intestinal IRI, specifically regarding how exosomes derived from either intestinal tissue or distant organs can modulate the pathophysiological progression of intestinal IRI. This review systematically evaluates the mechanistic roles of exosomes in intestinal IRI and their involvement in post-intestinal IRI multiple organ dysfunction, aiming to establish a theoretical foundation for therapeutic interventions and future research directions.
Keywords: Exosomes, ischemia-reperfusion injury, Intestinal ischemia-reperfusion injury, Intestinal injury, Multiorgan injury
Received: 24 Nov 2024; Accepted: 03 Apr 2025.
Copyright: © 2025 Ye, Yu, Nie, Wang, Mu and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bin Lu, Zigong Fourth People's Hospital, Zigong, Sichuan, China
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