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REVIEW article
Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1533141
Crosstalk between Bile Acids and Gut Microbiota: A Potential Target for Precancerous Lesions of Gastric Cancer
Provisionally accepted- 1 Gansu University of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, China
- 2 Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, China
As a critical juncture in the pathological continuum from gastritis to gastric cancer, precancerous lesions of gastric cancer (PLGC) are increasingly prevalent, significantly undermining the health of the global population. The primary constituents of bile, specifically bile acids (BAs), disrupt the equilibrium of gastric hormone secretion and compromise the structural integrity of the gastric mucosa, thereby facilitating gastric oncogenesis. Moreover, gut microbiota modulate host physiological and pathological processes through immune response regulation, metabolic pathway interference, and direct interaction with gastric tumor cells. Extensive research has elucidated that the metabolic dysregulation of BAs and gut microbiota, in concert with the resultant impairment of the gastric mucosa, are central to the pathogenesis of PLGC. In anticipation of future clinical preventive and therapeutic strategies, this review collates recent insights into the roles of BAs and gut bacteria in PLGC, examining their interplay and significance in the pathogenic mechanism of PLGC.
Keywords: Precancerous lesions of gastric cancer (PLGC), Bile acids (BAs), Gut Microbiota, Crosstalk mechanism, Traditional Chinese Medicine
Received: 23 Nov 2024; Accepted: 28 Feb 2025.
Copyright: © 2025 Zhang, Zhong, Shen and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhongyang Song, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.