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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1530371
Preventive Administration of Shengmaiyin: A Novel Approach to Counteract Heatstroke-Induced Coagulopathy in Rats
Provisionally accepted
Longping He 1
Zhuqing Luo 1 Lichun Zhang 1
Xingping Deng 1 Lincui Zhong 1
Qingwei Lin 1
Qingbo Zeng 2 Ye Zhou 1
Jingchun Song 1*- 1 the 908th Hospital of Chinese PLA Logistic Support Force, Nanchang, China
- 2 Nanchang Hongdu Hospital of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China
Background: Coagulation disorders play a pivotal role in the elevated mortality rates associated with exertional heatstroke (EHS).To investigate the impact of Shengmai Yin Oral Liquid (SMY) on heatstrokeinduced coagulopathy (HIC) in rats with EHS and to elucidate the underlying mechanisms.Methods: A cohort of eighteen male SPF-grade SD rats, each implanted with a telemetric temperature capsule, were randomly allocated to three groups: a normal control (NC) group, an EHS group, and an SMY group (n=6 per group). The SMY group received SMY orally at a dosage of 0.02 ml/(g•d) for a period of five consecutive days. Both the EHS and SMY groups were subjected to exercise in a climate-controlled chamber maintained at 40°C with 70% relative humidity until signs of exhaustion and a core body temperature of 42°C were reached, with the duration and distance of their exercise being meticulously documented. Histopathological assessments were performed on the liver, kidney, lung, duodenum, and heart of the rats. Blood samples were collected to measure prothrombin time (PT), activated partial thromboplastin time (APTT), platelet count, and levels of lactic acid (Lac), thrombomodulin (TM),
Keywords: Shengmaiyin, Exertional heatstroke, coagulopathy, Proteomics, Xpnpep2
Received: 18 Nov 2024; Accepted: 18 Feb 2025.
Copyright: © 2025 He, Luo, Zhang, Deng, Zhong, Lin, Zeng, Zhou and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jingchun Song, the 908th Hospital of Chinese PLA Logistic Support Force, Nanchang, China
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