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REVIEW article
Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1529375
This article is part of the Research TopicEpigenetic Modifications and Cardiovascular DiseasesView all 4 articles
The Biology of Exosomes and Exosomal Non-coding RNAs in Cardiovascular Diseases
Provisionally accepted- 1Department of Pharmacy, Children’s Hospital of Nanjing Medical University, Nanjing, Liaoning Province, China
- 2Department of Pharmacy, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China
- 3Department of Pharmacy, The Second Hospital of Tianjin Medical University, Tianjin, China
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Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, both in developed and developing countries. Despite the implementation of various measures in clinical practice that have shown certain curative effects, poor prognosis and irreversible pathological cardiac remodeling continue to limit the therapeutic effect of CVDs. there are still many new mechanisms worth exploring for the regulation of CVDs. Previous studies have highlighted the potential applicability of exosomes in CVDs, and significant research has been conducted in this area. In this review, we summarize the physiological mechanism of exosomes and the basic research achievements in regulating CVDs via exosomal non-coding RNAs. We also discuss the limitations and prospects of exosome application in CVDs treatment.
Keywords: Exosomes, non-coding RNAs, Cardiovascular Diseases, biomarker, intercellular delivery systems
Received: 16 Nov 2024; Accepted: 07 Apr 2025.
Copyright: © 2025 Gan, Guo, Dong and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chuan Sun, Department of Pharmacy, Children’s Hospital of Nanjing Medical University, Nanjing, Liaoning Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.