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REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1528671
This article is part of the Research TopicReviews in Ethnopharmacology: 2025View all 14 articles
Research advances in traditional Chinese Medicine formulae and active components targeting lipid metabolism for hepatocellular carcinoma therapy
Provisionally accepted- 1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
- 2School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Hong Kong Region, China
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Hepatocellular carcinoma (HCC) has a relatively poor prognosis and a high degree of malignancy. However, the therapeutic drugs are limited. In recent years, abnormal lipid metabolism and its important role in HCC has been reported, and emerging studies found that some formulae and active components of traditional Chinese medicine (TCM) can regulate abnormal lipid metabolism in HCC, showing their good application prospects. Therefore, this article summarizes the changes and the roles of lipid metabolites in HCC progression, and discusses the role of formulae and active components of TCM for the treatment of HCC based on their regulation on abnormal lipid metabolism. A deeper understanding of their relationship may help the precise use of these formulae and active components in HCC.
Keywords: Hepatocellular Carcinoma, Lipid Metabolism, Traditional Chinese Medicine, Formulae, Active components
Received: 15 Nov 2024; Accepted: 11 Apr 2025.
Copyright: © 2025 Liu, Yang, Yu, Li, Zhao, LU, Lyu and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaojuan He, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.