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REVIEW article

Front. Pharmacol.
Sec. Neuropharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1528544
This article is part of the Research Topic Potential Therapeutic Approaches of Female Hormones in the Brain View all 5 articles

Using estrogen and progesterone to treat Premenstrual Dysphoric Disorder, Postnatal Depression and Menopausal Depression

Provisionally accepted
Eveline Mu Eveline Mu *Jayashri Kulkarni Jayashri Kulkarni
  • Monash University, Melbourne, Victoria, Australia

The final, formatted version of the article will be published soon.

    Female gonadal hormones, particularly estrogen and progesterone, are not only central to reproductive health but also play a crucial role in regulating mood, cognition, and overall brain health. These hormones have a significant impact on the central nervous system, influencing key processes such as neurotransmission, neuroplasticity, and brain development.Increasing evidence shows that hormonal fluctuations contribute to the onset and progression of mental health disorders that disproportionately affect women, particularly premenstrual dysphoric disorder (PMDD), postnatal depression (PND), and menopausal depression. This paper explores the current evidence regarding the neurobiological effects of female hormones on the brain and discusses the therapeutic approaches in conditions such as PMDD, postnatal depression, and menopausal depression

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    Received: 15 Nov 2024; Accepted: 04 Feb 2025.

    Copyright: © 2025 Mu and Kulkarni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Eveline Mu, Monash University, Melbourne, 3800, Victoria, Australia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.