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REVIEW article
Front. Pharmacol.
Sec. Neuropharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1528538
Crosstalk between neuroinflammation and ferroptosis: Implications for Parkinson's disease progression
Provisionally accepted- 1 College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China
- 2 Cardiovascular Surgery Department, Second Hospital of Jilin University, Changchun, China
- 3 Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (CAS), Changchun, China
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and the aggregation of α-synuclein. Neuroinflammation is triggered by the activation of microglia and astrocytes, which release pro-inflammatory factors that exacerbate neuronal damage. This inflammatory state also disrupts iron homeostasis, leading to the occurrence of ferroptosis. Ferroptosis is characterized by lipid peroxidation of cell membranes and iron overload. Abnormal accumulation of iron in the brain increases oxidative stress and lipid peroxidation, further aggravating neuroinflammation and damage to dopaminergic neurons. Natural products have garnered attention for their antioxidant, anti-inflammatory, and neuroprotective properties, with many plant extracts showing promising therapeutic potential in PD research. This study further investigates the potential therapeutic roles of various natural products in regulating neuroinflammation and ferroptosis. The results suggest that natural products have significant therapeutic potential in modulating the interaction between neuroinflammation and ferroptosis, making them potential treatments for PD. Future research should further validate the safety and efficacy of these natural compounds in clinical applications to develop novel therapeutic strategies for PD.
Keywords: Parkinson's disease, Neuroinflammation, ferroptosis, Natural Products, Microglia, Astrocytes
Received: 15 Nov 2024; Accepted: 27 Feb 2025.
Copyright: © 2025 Guo, Wei, Yin and Ge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xunzhe Yin, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (CAS), Changchun, China
Yang Ge, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.