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REVIEW article
Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1528533
This article is part of the Research Topic Reviews in Pharmacology of Anti-Cancer Drugs: 2023 View all 8 articles
A Comprehensive Review of Schisandrin B's Preclinical Antitumor Activity and Mechanistic Insights from Network Pharmacology
Provisionally accepted- Affiliated Zhongshan Hospital of Dalian University, Dalian, China
As an active constituent in the extract of dried fruits of Schisandra chinensis, Schisandrin B exhibits diverse pharmacological effects, including liver protection, anti-inflammatory and anti-oxidant. Numerous studies have demonstrated that Schisandrin B exhibits significant antitumor activity against various malignant tumors in preclinical studies, which is achieved by inhibiting cell proliferation and metastasis and promoting apoptosis. As a potential novel antitumor agent, Schisandrin B holds broad application prospects. This review systematically elaborates on the antitumor effect of Schisandrin B and the related molecular mechanism, and preliminarily predicts its antitumor targets by network pharmacology, thereby pave the way for further research, development, and clinical application.
Keywords: Schisandra chinensis, Schisandrin B, antitumor, Molecular mechanisms, Network Pharmacology
Received: 15 Nov 2024; Accepted: 21 Jan 2025.
Copyright: © 2025 Fang, Pan, Wang, Wang and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shanshan Liang, Affiliated Zhongshan Hospital of Dalian University, Dalian, China
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