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SYSTEMATIC REVIEW article

Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1523713
This article is part of the Research Topic Preventing and Treating Liver Diseases: Medicinal and Food Plants, their metabolites as potential options View all 16 articles

Angel or devil: The dual roles of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside in the development of liver injury based on integrating pharmacological techniques: A systematic review

Provisionally accepted
Jiajie Jiang Jiajie Jiang 1*Qixiu Wang Qixiu Wang 2Qiang Wu Qiang Wu 1Bobin Deng Bobin Deng 3Cui Guo Cui Guo 1Jie Chen Jie Chen 1Jinhao Zeng Jinhao Zeng 1Yaoguang Guo Yaoguang Guo 1Xiao Ma Xiao Ma 1
  • 1 Chengdu University of Traditional Chinese Medicine, Chengdu, China
  • 2 Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
  • 3 Xi'an Medical University, Xi'an, China

The final, formatted version of the article will be published soon.

    Background and purpose: 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside(TSG) exhibits a dualistic pharmacological profile, acting as both a hepatoprotective and hepatotoxic agent, which is intricately linked to its interaction with multiple signaling pathways and its stereoisomeric forms, namely cis-SG and trans-SG. The purpose of this study is to evaluate both the hepatoprotective and hepatotoxic effects of TSG and give therapeutic guidance.This study performed a systematic search of eight databases to identify preclinical literature up until March 2024. The CAMARADES system evaluated evidence quality and bias.2 STATA and Python were used for statistical analysis, including dose-effect maps, 3D maps and radar charts to show the dose-time-effect relationship of TSG on hepatoprotection and hepatotoxicity.Results: After a rigorous screening process, a total of 24 studies encompassing 564 rodents were selected for inclusion in this study. The findings revealed that TSG exhibited bidirectional effects on the levels of ALT and AST, while also regulating the levels of ALT, AST, TNF-α, IL-6, serum TG, serum TC, SOD, MDA, IFN-γ, and apoptosis rate. The histological analysis of liver tissue confirmed the regulatory effects of TSG, and a comprehensive analysis revealed the optimal protective dosage range was 27.27-38.81 mg/kg/d and the optimal toxic dosage range was 51.93-76.07 mg/kg/d. TSG exerts the dual effects on liver injury (LI) through the network of Keap1/Nrf2/HO-1/NQO1, NF-κB, PPAR, PI3K/Akt, JAK/STAT and TGF-β pathways.: TSG could mediate the pathways of oxidation, inflammation, and metabolism to result in hepatoprotection (27.27-38.81 mg/kg/d) and hepatotoxicity (51.93-76.07 mg/kg/d).

    Keywords: 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucoside, Hepatotoxicity, Hepatoprotection, liver injury

    Received: 06 Nov 2024; Accepted: 03 Jan 2025.

    Copyright: © 2025 Jiang, Wang, Wu, Deng, Guo, Chen, Zeng, Guo and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiajie Jiang, Chengdu University of Traditional Chinese Medicine, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.