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REVIEW article

Front. Pharmacol.
Sec. Drug Metabolism and Transport
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1522814
This article is part of the Research Topic Liver Diseases and Their Impact on Drug Metabolism View all articles

Mini Review of Plant Products as Food Supplement against MSG-induced Liver Injury: Antioxidant, Oxidative Stress and Histological Prospects

Provisionally accepted
Dwi Pratiwi Kasmara Ramli Syamsuddin Dwi Pratiwi Kasmara Ramli Syamsuddin 1Erlina Abdullah Erlina Abdullah 2Zaliha Harun Zaliha Harun 3Fatmi Nirmala Sari Murdisal Budi Fatmi Nirmala Sari Murdisal Budi 1Norhashima Abd Rashid Norhashima Abd Rashid 1*Seong Lin Teoh Seong Lin Teoh 4*
  • 1 Department of Biomedical Science, Faculty of Applied Science, Lincoln University College, Petaling Jaya, Malaysia
  • 2 Department of Biotechnology, Faculty of Applied Science, Lincoln University College, Petaling Jaya, Malaysia
  • 3 Department of Nutrition, Faculty of Applied Science, Lincoln University College, Petaling Jaya, Malaysia
  • 4 Department of Anatomy, Faculty of medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia

The final, formatted version of the article will be published soon.

    Monosodium glutamate (MSG) is an odorless white solid crystalline derived from the amino acid glutamic acid. It is widely used as a flavor enhancer, but its excessive consumption has been associated with toxicity to various organs. In MSG-induced liver injury, few mechanisms have been identified, which started with the generation of reactive oxygen species that leads to oxidative stress which further causes liver injury. In response to this health concern, there is growing interest in various plant products such as plant extracts, flavonoids and phenolic compounds that were able to minimize oxidative stress, serum transaminases and scavenge free radicals in the liver after MSG administration. This review explores the potential of various plant products as dietary supplements to MSG-induced liver injury, focusing on their antioxidant activities, modulatory effects on liver function markers, and histological outcomes.By compiling this evidence, this review provides insights into their potential as preventive strategies against MSG-related liver toxicity, supporting their inclusion in dietary regimens for the maintenance of liver function.

    Keywords: Monosodium glutamate, liver injury, Oxidative Stress, Herbal Medicine, Plant products, Complementary medicine

    Received: 05 Nov 2024; Accepted: 02 Jan 2025.

    Copyright: © 2025 Ramli Syamsuddin, Abdullah, Harun, Murdisal Budi, Abd Rashid and Teoh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Norhashima Abd Rashid, Department of Biomedical Science, Faculty of Applied Science, Lincoln University College, Petaling Jaya, Malaysia
    Seong Lin Teoh, Department of Anatomy, Faculty of medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.