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REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 |
doi: 10.3389/fphar.2025.1521235
Progress in the study of bioactivity, chemical composition and pharmacological mechanism of action in Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb
Provisionally accepted
Qi Xiong 1
Zhuoran Li 1* Defeng Yang 2*
Xinze Liu 3
Wanxu Pu 1 Xitao Yue 1* Kaikai Jia 1*
Xilin Wan 3* Yuanjun Zou 1*- 1 Changchun University of Chinese Medicine, Changchun, China
- 2 Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
- 3 Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, China
The Latin name of Wolfiporia cocos is Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb, it a medicinal and edible mushroom belonging to the family Polyporaceae. Traditional Chinese medicine believes that it can strengthen the spleen, diuretic, tranquillise the mind and dispel dampness. So far, the chemical and active metabolites isolated and extracted from Wolfiporia cocos are mainly polysaccharides, triterpenoids, and sterols. Modern pharmacology has found that these chemical and active metabolites have a wide range of pharmacological effects, including antitumour, antioxidation, anti-inflammatory, immunomodulation, regulation of intestinal flora, regulation of glycolipid metabolism, and improvement of organ function. By applying Poria cocos, Poria, Wolfiporia cocos, Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb as search terms, we searched all the relevant studies on Poria cocos from Web of Science and PubMed databases and classified these categories of chemical and active metabolites according to the main research content of each literature and summarized its mechanism of action, updated its latest research results, and discussed the direction of further research in the future to provide a better reference for future clinical applications with better therapeutic effects and potential medicinal value.
Keywords: Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb, polysaccharide, Triterpenoid metabolites, active metabolites, mechanism of action
Received: 01 Nov 2024; Accepted: 06 Feb 2025.
Copyright: © 2025 Xiong, Li, Yang, Liu, Pu, Yue, Jia, Wan and Zou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhuoran Li, Changchun University of Chinese Medicine, Changchun, China
Defeng Yang, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
Xitao Yue, Changchun University of Chinese Medicine, Changchun, China
Kaikai Jia, Changchun University of Chinese Medicine, Changchun, China
Xilin Wan, Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China
Yuanjun Zou, Changchun University of Chinese Medicine, Changchun, China
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