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SYSTEMATIC REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1520039
This article is part of the Research Topic Herbal Medicine for the Treatment of Chronic Metabolic Diseases, Volume II View all 15 articles
Efficacy and safety of Tanshinone capsule in Acne vulgaris:a systematic review and meta-analysis
Provisionally accepted
Yutong Deng 1*
Ruli Feng 1
Bo Hu 2
Xuewen Ren 3 Fengchuan Zhang 2
Huishang Feng 4 Xuewan Wang 1 Yatong Li 1 Tangyunni Liu 1 Lingling Cai 2* Yuanwen Li 2*- 1 Beijing University of Chinese Medicine, Beijing, China
- 2 Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, Beijing, China
- 3 Shanxi Traditional Chinese Medical Hospital, Taiyuan, Shanxi Province, China
- 4 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, Beijing Municipality, China
Objectives: To evaluate the efficacy and safety of Tanshinone capsule as a complementary therapy in managing of Acne Vulgaris.A systematic search of six databases was conducted to identify relevant randomized controlled trials (RCTs) from each database for nearly 20 years (from Jan 1, 2004, to June 1, 2024). The Cochrane Handbook was used to evaluate the risk of bias. Meta-analysis was performed using Review Manager 5.4.1, and publication bias was assessed the Stata SE 12.0 software. GRADEpro was used to assess the quality of the evidence.Results: A total of 2,969 participants from 28 studies were included. We found that Tanshinone capsules can reduce acne recurrence rates [ risk ratio (RR) 0.44, 95% confidence interval (CI): 0.34 to 0.57, p < 0.00001]; downregulate levels of necrosis factor-alpha (TNF-α) [ mean difference (MD) 0.44, -10.18, 95% CI: -13.57 to -8.04, p
Keywords: Tanshinone capsule, Acne Vulgaris, Meta-analysis, Systematic review, randomized controlled trial 1.Introduction
Received: 30 Oct 2024; Accepted: 10 Mar 2025.
Copyright: © 2025 Deng, Feng, Hu, Ren, Zhang, Feng, Wang, Li, Liu, Cai and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yutong Deng, Beijing University of Chinese Medicine, Beijing, China
Lingling Cai, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, Beijing, China
Yuanwen Li, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.